Year: 2019
Type: review
Abstract: The lung presents a unique challenge for iron homeostasis. The entire airway is in direct contact with the environment and its iron particulate matter and iron-utilizing microbes. However, the homeostatic and adaptive mechanisms of pulmonary iron regulation are poorly understood. This review provides an overview of systemic and local lung iron regulation, as well as the roles of iron in the development of lung infections, airway disease, and lung injury. These mechanisms provide an important foundation for the ongoing development of therapeutic applications.
Source: Pharmaceuticals
DOI: 10.3390/ph12010030
Authors: Vida Zhang, Elizabeta Nemeth, Airie Kim
Institution: University of California, Los Angeles
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,013
OpenAlex ID: W2913793261