Year: 2019
Type: article
Abstract: is ambiguous, particularly in persons living with HIV (PLWH) receiving antiretroviral therapy (ART). Several factors potentially contribute to discrepancies between results in the literature, including differences in integration sites, functional proviral load, sampling bias, and stochastic PCR amplification. Recent studies into genomic features of cytosine methylation sites in mammalian genes offer potentially significant insights into this mechanism. Here, we discuss the importance of these factors in the context of the HIV.
Source: mBio
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funders: U.S. Department of Veterans Affairs, James B. Pendleton Charitable Trust, National Institutes of Health, Center for AIDS Research, University of Washington, Veterans Affairs San Diego Healthcare System, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1020090316, G1392409791, Perturbing the HIV Reservoir with Immune Stimulation, G3728100861, G3972098914, G4636128709, G4663250162, G5202045387, G5211237770, The Prostate as a Reservoir for Residual Replication, Comparative Retroviral Epigenomics, G7987025476, G8644636908, G8752558285, G9000052578, G9000062705, G9000071207, G9000124410, G9000127776, G9000148206, G9000165063, G9000283385, G9000306411, G9000316408, G9000323189, G9000327858, San Diego Center for AIDS Research (SD CFAR), HIV Neurobehavioral Research Center
OpenAlex ID: W2914155940