Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function
Year: 2019
Type: article
Abstract: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV + ) and somatostatin (SST + ) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST + cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
Source: Cell Reports
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
Funders: National Science Foundation, U.S. Department of Defense, Gladstone Institutes, National Institutes of Health, University of California, San Francisco, National Institute of Mental Health, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
Awards: G1432555021, Seismological Investigations of Earthquakes and Deep Earth Structure, G2302581481, G3596311957, G396635267, G4042315489, G4395360849, G4577585030, Graduate Research Fellowship Program (GRFP), G532075215, G5833123316, G6182320379, G6480478911, G661255219, G7104779986, G716694877, G8078861302, Genetic dissection of auditory circuit assembly, G979126022
OpenAlex ID: W2914387173