Association Between Water Fluoridation and Income-Related Dental Caries of US Children and Adolescents
Year: 2019
Type: article
Abstract: and 6′-sialyllactose (probiotic group, 472 [159] μmol/mL; control group, 567 [179] μmol/mL; P = .03).These changes are consistent with a change in select pathways in overall HMO biosynthetic machinery (Figure , B).Conclusions | Although HMO composition is largely genetically determined, maternal probiotic supplementation during late stages of pregnancy may change the HMO composition in human milk.It is unknown whether the change is specific to the probiotics used in this study, and findings need to be confirmed by other studies.In this case, we hypothesize a shift from 6′-sialylation to 3′-sialylation and toward type-2 core structures in HMOs.Maternal diet, medications, and microbiome may be important factors modulating a mother's colostrum HMO levels that should be considered when assessing biological effects suspected to be mediated by HMO levels.Ultimately, modifying mothers' milk HMO composition may open new avenues for disease modification in infants who are breastfed.
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2914877206