Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop
Year: 2018
Type: article
Abstract: BACKGROUND: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. METHODS: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. RESULTS: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. CONCLUSIONS: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.
Source: Public Health Genomics
DOI: 10.1159/000496495
Authors: Christos Nikolaidis, Chang Ming, Carla Pedrazzani, Tina van der Horst, Andrea Kaiser-Grolimund, Zanfina Ademi, Rosmarie Bührer-Landolt, Nicole Bürki, Maria Caiata-Zufferey, Victoria Champion, Pierre O. Chappuis, Carmen Kohler, Tobias E. Erlanger, Rossella Graffeo, Heather Hampel, Karl Heinimann, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christian Monnerat, Laurel L. Northouse, Olivia Pagani, Nicole Probst-Hensch, Manuela Rabaglio, Eveline Schoenau, Eric J.G. Sijbrands, Monika Taborelli, Corinne Urech, Valeria Viassolo, Simon Wieser, Maria C. Katapodi
Institutions: University of Basel, University of Applied Sciences and Arts of Southern Switzerland, Monash University, University Hospital of Bern, University Hospital of Basel, Indiana University Indianapolis, Indiana University, University of Geneva, University Hospital of Geneva, Istituto Oncologico della Svizzera Italiana, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, University of Michigan, Swiss Tropical and Public Health Institute, Erasmus MC, ZHAW Zurich University of Applied Sciences
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2914888697