Year: 2018
Type: conference-paper
Abstract: We present a packaging concept for an ingestible sensing capsule, which utilizes biodegradable polymers to target the sensors to specific areas of the gut.Interdigitated electrodes (IDE) are inserted into 3D-printed capsules with embedded gratings that are filled with pharmaceutical polymers tuned to dissolve at a specific pH threshold.Sensors, housed within a 3D-printed package accessible only by the gratings, are connected to a microcontroller capable of transmitting data to a smartphone via Bluetooth Low-Energy (BLE).The system is tested with varying amounts and types of enteric coatings over the gratings, used toward optimizing control over timed polymer dissolution.This represents a minimally-invasive strategy toward in situ sampling and analysis at pH-targeted locations in the gastrointestinal (GI) tract.
Authors: G.E. Banis, L.A. Beardslee, J.M. Stine, R. Ghodssi
Institution: University of Maryland, College Park
Language: English
Subfield: Bioengineering
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2914908505