Diverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance
Year: 2019
Type: article
Abstract: The Mycobacterium tuberculosis lineage 4 strains CDC1551 and H37Rv develop tolerance to multiple antibiotics upon macrophage residence. To determine whether macrophage-induced tolerance is a general feature of clinical M. tuberculosis isolates, we assessed macrophage-induced drug tolerance in strains from lineages 1-3, representing the other predominant M. tuberculosis strains responsible for tuberculosis globally. All 3 lineages developed isoniazid tolerance. While lineage 1, 3, and 4 strains developed rifampin tolerance, lineage 2 Beijing strains did not. Their failure to develop tolerance may be explained by their harboring of a loss-of-function mutation in the Rv1258c efflux pump that is linked to macrophage-induced rifampicin tolerance.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,382
Funders: Wellcome Trust, Department of Biotechnology, Ministry of Science and Technology, India, Indian Council of Medical Research, National Institute of Technology Rourkela, National Institute for Research in Tuberculosis, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases
Awards: G1097973369, G1237558972, G1406022370, G3274069329, Fundamental and therapeutic insights into tuberculosis from the zebrafish and its application to humans., G4743653848, Fundamental and therapeutic insights into tuberculosis from the zebrafish and its application to humans., G5014284870, Cambridge-Chennai Centre Partnership on Antimicrobial Resistant Tuberculosis, G6386211424, G9000006243, G9000030597, G9000327216, G916267468
OpenAlex ID: W2914975342