Work

The role of m6A RNA methylation in cancer

Year: 2019

Type: review

Abstract: N6-methyladenosine (m6A), the most abundant internal modification of RNA in eukaryotic cells, has gained increasing attention in recent years. The m6A modification affects multiple aspects of RNA metabolism, ranging from RNA processing, nuclear export, RNA translation to decay. Emerging evidence suggests that m6A methylation plays a critical role in cancer through various mechanisms. Moreover, m6A methylation has provided more possibilities for the early diagnosis and treatment of cancers. In this review, we focus on m6A-associated mechanisms and functions in several major malignancies and summarize the dual role of m6A methylation as well as its prospects in cancer.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2019.108613

Authors: Ting Sun, Ruiyan Wu, Liang Ming

Institutions: First Affiliated Hospital of Zhengzhou University, Fudan University Shanghai Cancer Center

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000