Work

Gene Delivery: Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium (Adv. Mater. 8/2019)

Year: 2019

Type: article

Abstract: In vitro transcribed messenger RNA is nebulized using poly(beta amino esters) for inhalable delivery to the lung as described by Daniel G. Anderson and co-workers in article number 1805116. Hyperbranched polymers are synthesized, which form stable mRNA-polyplexes that distribute uniformly throughout the lungs of mice and are translated to reporter protein in the lung epithelium.

Source: Advanced Materials

DOI: 10.1002/adma.201970053

Authors: Asha Kumari Patel, James C. Kaczmarek, Suman Bose, Kevin J. Kauffman, Faryal Mir, Michael W. Heartlein, Frank DeRosa, Robert Langer, Daniel G. Anderson

Institutions: University of Nottingham, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Translate Bio (United States), Harvard–MIT Division of Health Sciences and Technology

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2916319300

FWCI: 0.331

Cites:

Cited by: 9

Related to: 10