Year: 2019
Type: article
Abstract: Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research about the role of SUMOylation in the development of different brain regions.
Source: PLoS ONE
Authors: Fernando Josa-Prado, Jia Luo, Philip Rubin, Jeremy M. Henley, Kevin A. Wilkinson
Institutions: University of Bristol, Universidad Alfonso X el Sabio
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,595
Awards: G2309074070, Synapses: from molecules to higher brain function and diseases, G3787010340, Mechanisms and consequences of synaptic SUMOylation in health and disease, G5950701986, G629397677, G6773374932, G77945283, Mechanisms and consequences of presynaptic protein SUMOylation in the regulation of neurotransmitter release, Understanding the roles of SUMO proteases in neuronal function and viability
OpenAlex ID: W2916488160