Work

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration

Year: 2019

Type: article

Abstract: Significance Traumatic bone injuries or deformities are among the most common conditions that require surgical intervention affecting patients in the United States today. Current treatment options suffer shortcomings, clearly demonstrating a clinical need for tissue replacement techniques. An ideal treatment consists of a scaffold that promotes regeneration, matches the chemical and mechanical properties of bone, and degrades with a timeline matching the healing process. However, this ideal scaffold has not been realized. Here, we present a degradable, graphene-based material that mimics the chemical and mechanical composition of bone, promotes differentiation of stem cells, and leads to the formation of new bone in an animal model.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1815434116

Authors: Anne M. Arnold, Brian D. Holt, Leila Daneshmandi, Cato T. Laurencin, Stefanie A. Sydlik

Institutions: Carnegie Mellon University, University of Connecticut, UConn Health

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases