Work

Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect

Year: 2019

Type: article

Abstract: CFU reduction in bacterial density. Furthermore, addition of apotransferrin significantly reduced the emergence of ciprofloxacin-resistant subpopulations compared to monotherapy. These data demonstrate that decreasing the rate of bacterial replication with apotransferrin in combination with antimicrobial therapy represents an opportunity to increase the magnitude of the bactericidal effect and to suppress the growth rate of drug-resistant subpopulations.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00112-19

Authors: Paul G. Ambrose, Brian D. VanScoy, Brian M. Luna, Jun Yan, Amber Ulhaq, Travis B. Nielsen, Sue Rudin, Kristine Hujer, Robert A. Bonomo, Luis Actis, Eric Skaar, Brad Spellberg

Institutions: Institute for Clinical Pharmacodynamics (United States), University at Buffalo, State University of New York, University of Southern California, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Vanderbilt University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Agency for Healthcare Research and Quality, National Institute of Allergy and Infectious Diseases

Awards: Humanized Monoclonal Antibody to Treat Acinetobacter Infections, G230942255, G3913467187, Humanized Monoclonal Antibodies to Treat Acinetobacter Infections, G5547517824, MAb Passive Vaccination against Acinetobacter baumannii, Transferrin Combination Therapy to Address Antimicrobial Resistance, Transferrin As a Novel Approach to Combat Mucormycosis, G8462354700, G8465949821, Diabetes and Inflammation During Infection, Understanding B-Lactam Resistance in Acinetobacter baumannii, G910211830

OpenAlex ID: W2916737756

FWCI: 0.422

Cites: 15

Cited by: 9

Related to: 10