Work

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

Year: 2019

Type: article

Study design: Observational Study

Source: Annals of Surgical Oncology

DOI: 10.1245/s10434-019-07269-z

Authors: So Nakamura, Yoshihiko Sadakari, Takao Ohtsuka, Takafumi Okayama, Yohei Nakashima, Yoshitaka Gotoh, Kiyoshi Saeki, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Hideya Onishi, Yoshinao Oda, Michael Goggins, Masafumi Nakamura

Institutions: Kyushu University, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Japanese Foundation for Research and Promotion of Endoscopy, Japan Society for the Promotion of Science

Awards: Development of biomarkers target on exosomes which derived from stromal cells in premalignant microenvironment., Biomarkers in exosome extracted from duodenal fluid for early detection of pancreatobiliary malignancy, Development of therapy for inhibition of fibrosis of schirrhous type gastric cancer using Hh inhibitor aiming establishment of immunosurveilance, RNA / protein analysis in portal blood exosomes to detect a high risk group of colorectal cancer liver metastases, Elucidating the mechanisms of pre-metastatic niche formation by pancreatic cancer exosomes, Analysis of TrkB/BDNF-Hh crosstalk pathway for development of therapeutic strategy against lung NET, Development of new therapeutical strategy for gallbladder cancer targeting Gli2 signaling pathway, Analysis of S100 family proteins and exosomal microRNA in duodenal juice as a diagnostic marker of pancreatic ductal adenocarcinoma, Development of new therapeutical strategy for lung NET by inhibiting Hh/Notch signaling targeting RBPJ, Development of new therapeutic strateg for pancreatic cancer targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3), Elucidation of microenvironment induction mechanism by exosome in liver metastasis and peritoneal dissemination of colorectal cancer

OpenAlex ID: W2916808232

FWCI: 3.969

Cites: 32

Cited by: 95

Related to: 10