Work

Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases

Year: 2019

Type: editorial

Abstract: High Resolution Image Download MS PowerPoint Slide In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and -B enzyme expression or activity. MAO-A and MAO-B are critical for understanding monoaminergic pathways in psychiatric addiction disorders, and more recently in neurodegenerative disorders with MAO-B expression in astrogliosis. Unique radiochemical innovations have been shown for neuroimaging of MAOs including the clinical translation of irreversible propargylamine-based suicide inhibitors, application of deuterium-substitution to slow down metabolism, development of trapped metabolite imaging agents, and unique 11 C-carbonylation chemistry toward novel high-affinity reversibly binding inhibitors.

Source: ACS Chemical Neuroscience

DOI: 10.1021/acschemneuro.9b00081