Work

Angiogenic and wound healing potency of fermented virgin coconut oil: in vitro and in vivo studies.

Year: 2017

Type: article

Abstract: OBJECTIVE: assays. METHODS: Human umbilical vein endothelial (HUVEC), fibroblast (CCD-18) and retinal ganglion (RGC-5) cells were cultured in medium containing different concentrations of FVCO. The proliferation, migration and morphological changes of cells were determined. The angiogenic effect of FVCO was evaluated by rat aortic assay. The therapeutic effect of FVCO on wound healing was further assessed in a wound excision model in Sprague Dawley rats. The expression of phospho-VEGFR2 (vascular endothelial growth factor receptor 2) in HUVECs was detected by Western blot. RESULTS: = 0.006 and 0.000, respectively). CONCLUSION: Our study confirms a high angiogenic and wound healing potency of FVCO that might be mediated by the regulation of VEGF signing pathway.

Source: Europe PMC (PubMed Central)

Authors: Ahmad H Ibrahim, Haibo Li, Sawsan S Al-Rawi, Aman Shah Abdul Majid, Omar Am Al-Habib, Xiaobo Xia, Amin Ms Abdul Majid, Dan Ji

Institutions: University of Zakho, Central South University, Xiangya Hospital Central South University, Australian National University, Quest International University Perak, The First People's Hospital of Changde

Language: English

Topic: Coconut Research and Applications

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2917360303

FWCI: 1.685

Cites: 19

Cited by: 21

Related to: 10