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Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects

Year: 2019
Type: article
Abstract: The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from F-FDG, F-FDS is virtually available at any PET facility with radiochemistry infrastructure.
DOI: 10.1097/rlu.0000000000002494
Authors: Rudolf A. Werner, Alvaro A. Ordonez, Julian Sanchez-Bautista, Charles Marcus, Constantin Lapa, Steven P. Rowe, Martin G. Pomper, Jeffrey P. Leal, Martin A. Lodge, Mehrbod S. Javadi, Sanjay K. Jain, Takahiro Higuchi
Institutions: Johns Hopkins University, University of Würzburg, Johns Hopkins Medicine, Universitätsklinikum Würzburg, Okayama University, National Cerebral and Cardiovascular Center
Language: English
Field: Medicine
Open Access status: hybrid
Funders: European Commission, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, National Institutes of Health, Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute
Awards: G1899197870, G434337789, G4494584867, Cardiovascular Molecular Imaging for Personalized Tailored Treatment, G9000052960, Construction of heart failure personalized medicine strategy by heart molecular imaging international collaborative research
OpenAlex ID: W2917717859
FWCI: 3.141
Cites: 9
Cited by: 33
Related to: 10