Work

Sulfamate Esters Guide C(3)-Selective Xanthylation of Alkanes

Year: 2019

Type: article

Abstract: Owing to the pervasiveness of hydroxyl groups in natural isolates, alcohol derivatives are alluring directing groups. Herein, an alcohol-derived sulfamate ester guides the light-initiated xanthylation of primary, secondary, or tertiary centers. This process enables formal directed deuteration, azidation, thiolation, and vinylation reactions.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.9b00105

Authors: Suraj K. Ayer, J. L. Roizen

Institution: Duke University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Duke University, North Carolina State University, National Institute of General Medical Sciences

Award: Exploiting Masked Alcohols to Guide Atom-Transfer Reactions