Impact of conditioning regimen on peripheral blood hematopoietic cell transplant
Year: 2019
Type: article
Study design: Observational Study
Abstract: AIM: To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/- total body irradiation (TBI) on outcomes after peripheral blood hematopoietic cell transplant (PBHCT). METHODS: Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT and treated between 2001 and 2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank test. RESULTS: = 0.02). CONCLUSION: TBI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PBHCT. Immune cell subsets may predict improved survival after unmanipulated PBHCT.
Authors: Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy, Theresa Hahn
Institution: Roswell Park Comprehensive Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2918137152