Year: 2019
Type: article
Abstract: Choice of first-line antidepressants for depression has been debated in psychiatric journals over the last 9 months, in relation to the widely reported meta-analysis by Cipriani et al in the Lancet, comparing 21 antidepressants for efficacy and tolerability.1 They found that agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more effective than other antidepressants. 1 They also found agomelatine, citalopram, escitalopram, fluoxetine, sertraline, and vortioxetine to be relatively better tolerated than others. 1 Three antidepressants with higher efficacy also had relatively high acceptability: agomelatine, escitalopram, and vortioxetine.So should these antidepressants now be considered firstline choices for depression in primary care?
Authors: Tony Kendrick, David Taylor, Chris F Johnson
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2918453031