Work

Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs

Year: 2019

Type: article

Abstract: Glucose is the primary energy supply for metabolism and a versatile precursor for biomolecule synthesis. Cellular uptake of glucose mainly relies on two types of glucose transporters, the sodium gradient driven glucose symporter SGLT family and the facilitative uniporter GLUT family. Glucose uptake is markedly elevated in tumor cells to compensate for the less-efficient ATP production via glycolysis, a phenomenon known as the Warburg effect. Overexpression of GLUT family members GLUT1 or GLUT3 has been observed in various types of tumors, making them potential targets for novel drug discovery against cancer 1 .

Source: Cell Discovery

DOI: 10.1038/s41421-019-0082-1