Work

Comment on ‘Linear energy transfer incorporated intensity modulated proton therapy optimization’

Year: 2019

Type: letter

Abstract: Cao et al (2018) published an article on inverse planning based on dose-averaged linear energy transfer (LET). Their claim that the problem can be cast as a linear optimization model relies on an incorrect application of the Charnes-Cooper transformation. In this comment we show that their linear model is simlar to one where dose-averaged LET is multiplied with dose, explaining why their model was nonetheless able to improve the LET distribution.

Source: Physics in Medicine and Biology

DOI: 10.1088/1361-6560/aaffa6

Author: Bram L Gorissen

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Foundation for the National Institutes of Health, National Institutes of Health, National Cancer Institute

Awards: G1008646124, G1684365693, Improving the Clinical Effectiveness and Understanding of the Biophysical Basis

OpenAlex ID: W2919656125

Cites: 4

Cited by:

Related to: 10