Sensorimotor Integration during Rubber Hand Illusion in Normal Subjects and Subjects with Parkinson’s Disease
Year: 2018
Type: dissertation
Abstract: Rubber hand illusion (RHI) measures visuo-tactile multisensory integration. Non-motor symptoms are well recognized in Parkinson’s disease (PD) and PD patients have impaired sensation and sensorimotor integration. We hypothesized that 1) RHI decreases sensorimotor integration in healthy subjects 2) PD patients will show reduced RHI and less modulation of sensorimotor integration by RHI. We used transcranial magnetic stimulation to examine short- and long-latency afferent inhibition (SAI and LAI), which measures the influence of sensory input on the primary motor cortex (M1), and the posterior parietal cortex (PPC)-M1 interactions during RHI. In healthy subjects, we found reduced SAI and LAI during RHI, and stronger RHI correlated with greater inhibitory PPC-M1 interactions. PD patients showed normal RHI, but had no correlation between RHI strength and PPC-M1 interactions. Our results show that RHI modulates both early and late stages of sensorimotor integration in healthy subjects and this effect of RHI is altered in PD.
Source: TSpace (University of Toronto)
Author: Reina Isayama
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W2919708078