Work

Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

Year: 2019

Type: data-paper

Abstract: This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.

Source: Data in Brief

DOI: 10.1016/j.dib.2019.103784

Authors: María N. Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Aurelio M. Sueiro, Esteban Guitián, Felipe F. Casanueva, Richard W. Farndale, Masaaki Moroi, Stephanie M. Jung, María Pardo, Ángel García

Institutions: Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigación Sanitaria de Santiago, University of Cambridge

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $553

Funders: British Heart Foundation, Ministerio de Economía y Competitividad, Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, Xunta de Galicia, Universidade de Santiago de Compostela, European Regional Development Fund

Awards: G1450903212, GPVI-dimer, a specific target in ischaemic heart disease and stroke, G3876637791, Collagen-like peptides: synthetic tools to investigate vascular cell function in health and disease (renewal). ,, G4948256279, G5720423750, G8612360239, Defining the GPVI-dimer-fibrin interaction in collagen-independent thrombus formation. ,

OpenAlex ID: W2919723341

Cites: 5

Cited by: 5

Related to: 10