Work

Impact of Early Antiretroviral Therapy on Detection of Cell-Associated HIV-1 Nucleic Acid in Blood by the Roche Cobas TaqMan Test

Year: 2019

Type: article

Study design: Observational Study

Abstract: The Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test, v2.0 (the CAP/CTM assay), was used to quantify cell-associated HIV-1 (CAH) nucleic acid in peripheral blood mononuclear cells (PBMC) from well-characterized clinical specimens from HIV-1-infected individuals on antiretroviral therapy (ART). Chronically infected individuals on ART with no detectable plasma HIV-1 RNA demonstrated average CAH burdens of 3.2 HIV-1 log 10 copies/million cells.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.01922-18

Authors: Linda L. Jagodzinski, Mark M. Manak, Holly R. Hack, Ying Liu, Jennifer A. Malia, Joanna Freeman, Nittaya Phanuphak, Mark de Souza, Eugène D. Kroon, Donn J. Colby, Nitiya Chomchey, Michelle A. Lally, Nelson L. Michael, Jintanat Ananworanich, Sheila A. Peel

Institutions: Walter Reed Army Institute of Research, Henry M. Jackson Foundation, Thai Red Cross Society, Brown University, Miriam Hospital

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, Henry M. Jackson Foundation, National Institutes of Health, U.S. Army, National Institute of Allergy and Infectious Diseases, U.S. Military HIV Research Program, Medical Research and Materiel Command, Walter Reed Army Institute of Research, U.S. Army Medical Research Acquisition Activity

Awards: G1001402544, G1068410127, G1478707848, G1673984772, G4055603674, Preservation of adaptive immunity leads to HIV control upon treatment cessation., G7122330882, G7351293701

OpenAlex ID: W2920552495

FWCI: 1.119

Cites: 59

Cited by: 14

Related to: 10