Work

Ocular phenotypic consequences of a single copy deletion of the Yap1 gene (Yap1 +/-) in mice.

Year: 2019

Type: article

Abstract: Purpose: were determined in detail. Methods: and age-matched wild-type (WT) mice between eyelid opening (2 weeks after birth) and adulthood (2 months and 1 year after birth). Following euthanasia, enucleated eyes were characterized histologically. Results: mice at 1 year of age. Conclusions: gene in mice leads to complex ocular abnormalities, including microphthalmia, corneal fibrosis, anterior segment dysgenesis, and cataract.

Source: Europe PMC (PubMed Central)

Authors: Soohyun Kim, Sara M Thomasy, Vijay Krishna Raghunathan, Leandro B C Teixeira, Ala Moshiri, Paul FitzGerald, Christopher J Murphy

Institutions: University of California, Davis, University of Houston, University of Wisconsin–Madison

Language: English

Topic: Ocular Disorders and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Eye Institute

Awards: The Role of ARAP1 in Retinal Photoreceptor Homeostasis, Mechanotransduction in corneal disorders, Biophysical Cues and Corneal Wound Healing, KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium., VISION RESEARCH CORE GRANT

OpenAlex ID: W2920653292

FWCI: 1.45

Cites: 45

Cited by: 15

Related to: 10