INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma
Year: 2019
Type: article
Study design: Observational Study
Abstract: With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients’ outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187
Source: Future Oncology
Authors: Caitlin Costello, Faith E Davies, Gordon Cook, Jorge Vela-Ojeda, Jim Omel, Robert M Rifkin, Jesus Berdeja, Noemi Puig, Saad Z Usmani, Katja Weisel, Jeffrey A Zonder, Evangelos Terpos, Andrew Spencer, Xavier Leleu, Mario Boccadoro, Michael A Thompson, Dorothy Romanus, Dawn M Stull, Vania Hungria
Institutions: University of California San Diego, Moores Cancer Center, University of Arkansas Medical Center, University of Arkansas for Medical Sciences, St James's University Hospital, Mexican Social Security Institute, Centro Médico Nacional La Raza, Rocky Mountain Cancer Centers, Sarah Cannon, Complejo Hospitalario de Salamanca, Levine Cancer Institute, University Medical Center Hamburg-Eppendorf, University of Tübingen, Wayne State University, The Barbara Ann Karmanos Cancer Institute, National and Kapodistrian University of Athens, The Alfred Hospital, Alfred Health, Monash University, Inserm, Centre Hospitalier Universitaire de Poitiers, University of Turin, Aurora Health Care, Takeda Oncology (United States), São Germano Oncologia
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: CANCER CENTER SUPPORT GRANT
OpenAlex ID: W2920787201