Year: 2019
Type: review
Abstract: The ischemic penumbra is both a concept in understanding the evolution of cerebral tissue injury outcome of focal ischemia and a potential therapeutic target for ischemic stroke. In this review, we examine the evidence that angiogenesis can contribute to beneficial outcomes following focal ischemia in model systems. Several studies have shown that, following cerebral ischemia, endothelial proliferation and subsequent angiogenesis can be detected beginning four days after cerebral ischemia in the border of the ischemic core, or in the ischemic periphery, in rodent and non-human primate models, although initial signals appear within hours of ischemia onset. Components of the neurovascular unit, its participation in new vessel formation, and the nature of the core and penumbra responses to experimental focal cerebral ischemia, are considered here. The potential co-localization of vascular remodeling and axonal outgrowth following focal cerebral ischemia based on the definition of tissue remodeling and the processes that follow ischemic stroke are also considered. The region of angiogenesis in the ischemic core and its surrounding tissue (ischemic periphery) may be a novel target for treatment. We summarize issues that are relevant to model studies of focal cerebral ischemia looking ahead to potential treatments.
Authors: Masato Kanazawa, Tetsuya Takahashi, Masanori Ishikawa, Osamu Onodera, Takayoshi Shimohata, Gregory J del Zoppo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Endothelial Beta 1-integrins in Cerebral Vascular Barrier Integrity, Peripheral blood-derived mononuclear cells preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic stroke, The establishment of therapeutic strategies of microglial transplantation against chronic ischemic stroke, Neurovascular Adhesion Receptors and Barrier Integrity, Novel treatment using microglia preconditioned by oxygen glucose deprivation against cerebral hemorrhage, MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA, Endothelial Beta 1-integrins in Cerebral Vascular Barrier Integrity
OpenAlex ID: W2920941908