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Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population

Year: 2019
Type: article
Study design: Observational Study
Abstract: Visual disengagement has been hypothesized as an endophenotype for autism. In this study we used twin modelling to assess the role of genetics in basic measures of visual disengagement, and tested their putative association to autistic traits in the general population. We used the Gap Overlap task in a sample of 492 twins. Results showed that most of the covariance among eye movement latencies across conditions was shared and primarily genetic. Further, there were unique genetic contributions to the Gap condition, but not to the Overlap condition-i.e. the one theorized to capture visual disengagement. We found no phenotypic association between autistic traits and disengagement, thus not supporting the hypothesis of visual disengagement as an endophenotype for autistic traits.
DOI: 10.1007/s10803-019-03974-6
Authors: Monica Siqueiros Sanchez, Erik Pettersson, Daniel P. Kennedy, Sven Bölte, Paul Lichtenstein, Brian M. D’Onofrio, Terje Falck-Ytter
Institutions: Region Stockholm, Karolinska Institutet, Indiana University Bloomington, Indiana University, Uppsala University, Swedish Collegium for Advanced Study
Language: English
Open Access status: hybrid
Estimated APC paid: $2,690
OpenAlex ID: W2921188821
FWCI: 1.017
Cites: 71
Cited by: 12
Related to: 10