Work

SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathway

Year: 2017

Type: article

Abstract: SAMTOR joins the family The amino acid methionine is widely appreciated to have interesting effects on animal physiology. Diets low in methionine increase longevity and overall health, particularly glucose homeostasis. Gu et al. describe a potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms. They identify a protein that they named SAMTOR as a component of the nutrient-sensing pathway upstream of mTORC1. SAMTOR directly binds S-adenosylmethionine (SAM), a metabolite made from methionine, and is necessary for regulating mTORC1 in response to methionine. Science , this issue p. 813

Source: Science

DOI: 10.1126/science.aao3265

Authors: Xin Gu, Jose M. Orozco, Robert A. Saxton, Kendall J. Condon, Grace Y. Liu, Patrycja A. Krawczyk, Sonia M. Scaria, J. Wade Harper, Steven P. Gygi, David M. Sabatini

Institutions: Broad Institute, Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Harvard University

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

Awards: Elucidating the mechanism of leucine sensing by Sestrin2 upstream of mTORC1, Medical Scientist Training Program, Regulation of the mTOR Pathway by Nutrients, Novel Components of the mTORC1 and mTORC2 Pathways, Systematic discovery and functional analysis of the PARKIN modified proteome, Systematic Exploration of the Human Interactome, G6927874198, G7160503807, Pre-Doctoral Training in Biological Sciences, Regulation of PINK1 and PARKIN-Dependent Mitophagy, Determining the mechanism of aspartate sensing by the mTOR pathway, Cancer Center Support (Core) Grant, Ubiquitin‐mediated proteolysis and cell cycle control, G96767689

OpenAlex ID: W2767250022

FWCI: 17.42

Cites: 43

Cited by: 570

Related to: 10