Work

Getting a handle on lipid droplets: Insights into ER–lipid droplet tethering

Year: 2019

Type: article

Abstract: Lipid droplets (LDs) are hubs for lipid metabolism that form membrane contact sites with multiple organelles. In this issue, Hariri et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808119) reveal the functions of Mdm1-mediated endoplasmic reticulum (ER)–LD tethering in yeast and Datta et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808133) identify a role for the Mdm1 orthologue, Snx14, as an ER–LD tether that regulates lipid metabolism in human cells.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201902160

Authors: Truc B. Nguyen, James A. Olzmann

Institutions: University of California, Berkeley, Chan Zuckerberg Biohub San Francisco

Language: English

Topic: Lipid metabolism and biosynthesis

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: American Heart Association, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1969514110, G3064501752, The cell biology of lipid droplets: Regulation of lipid and energy homeostasis, G9000017533