Work

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Year: 2019

Type: article

Abstract: Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201902035

Authors: Praful R. Nair, Denis Wirtz

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute on Aging, National Cancer Institute

Awards: G1912770925, The Johns Hopkins Physical Sciences Oncology Center, G9000009912