Neurostructural Correlates of IL-1β rs16944 Polymorphism in Adolescents with and without Bipolar Disorder
Year: 2018
Type: dissertation
Study design: Observational Study
Abstract: Increased inflammation among youth with bipolar disorder (BD) is associated with increased illness severity. Functional inflammatory polymorphisms are associated with neurostructural changes in BD. This was examined for the first time in youth. T1-weighted images of 38 BD and 32 healthy controls (HCs) were processed through FreeSurfer to obtain cortical region of interest (ROI) volumes/surface area/thickness for dorsolateral prefrontal cortex and caudal anterior cingulate cortex, along with subcortical ROI volumes for hippocampus and amygdala. Our results show a main effect of interleukin (IL)-1β rs16944 in the lateral occipital cortex (LOC), along with a IL-1β rs16944-by-diagnosis interaction effect for a pars triangularis surface area cluster along with a LOC volume cluster. Our results suggest that the IL-1β rs16944 polymorphism is associated with neurostructural differences in youth with BD and HCs. Future studies including other imaging phenotypes and neurocognitive tasks are warranted to evaluate the relationship between IL-1β rs16944 and brain function.
Source: TSpace (University of Toronto)
Author: Daniel Shonibare
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2921712837