Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogs
Year: 2019
Type: article
Study design: Observational Study
Abstract: It is well established that immune thrombocytopenia (ITP) results from increased immune mediated platelet destruction (anti-platelets antibodies, autoreactive T cells, and reduction of regulatory T cells) along with impaired production in the bone marrow.1 The latter has been attributed to both cellular and humoral mediators that cause suppression of megakaryocyte production and maturation.2 Current standard first line therapy consists of corticosteroids, with or without intravenous Ig, achieving about 70-80% response rate. However, a consistent proportion of patients would relapse after corticosteroid discontinuation or tapering, and requires further therapy. ...
Source: Haematologica
Institutions: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Azienda Ospedaliera San Gerardo, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Palermo, Ospedale San Bortolo
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,157
OpenAlex ID: W2921737327