Investigating Nutritional Status in Moderate to Severe Alzheimer's Disease Patients Enrolled in a Randomized Controlled Trial with Nabilone
Year: 2018
Type: dissertation
Abstract: Nutritional status is of great clinical significance in Alzheimer’s disease (AD) patients as malnutrition can increase risk of morbidity, mortality and severity of neuropsychiatric symptoms. Due to a lack of pharmacological treatments for malnutrition, we investigate the use of nabilone, a synthetic cannabinoid, for the improvement of nutritional status. Patients were recruited from a clinical trial in AD patients with clinically significant agitation. Patients treated with nabilone did not have improved nutritional status over time as assessed by the Mini Nutritional Assessment-Short Form (b=-0.020 (95%CI -0.27 to 0.23), p=0.87) and body mass index (b=0.020 (95%CI -0.13 to 0.17), p=0.79). Safety outcomes did not significantly differ with respect to nutrition for patients receiving nabilone treatment. By identifying efficacious interventions to manage nutrition in an at-risk population, there may be potential to improve quality of life for AD patients.
Source: TSpace (University of Toronto)
Author: Chelsea Sherman
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2921795084