Work

Metabolic regulation of inflammasomes in inflammation

Year: 2019

Type: review

Abstract: Inflammasome activation and subsequent inflammatory cytokine secretion are essential for innate immune defence against multiple stimuli and are regarded as a link to adaptive immune responses. Dysfunction of inflammasome activation has been discovered at the onset or progression of infectious diseases, autoimmune diseases and cancer, all of which are also associated with metabolic factors. Furthermore, many studies concerning the metabolic regulation of inflammasome activation have emerged in recent years, especially regarding the activity of the NLRP3 inflammasome under metabolic reprogramming. In this review, we discuss the molecular mechanisms of the interactions between metabolic pathways and inflammasome activation, which exerts further important effects on various diseases.

Source: Immunology

DOI: 10.1111/imm.13056

Authors: Qiuli Yang, Ruichen Liu, Qing Yu, Yujing Bi, Guangwei Liu

Institutions: Beijing Normal University, Beijing Institute of Microbiology and Epidemiology

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China