Work

Uncovering the complex genetics of human personality: response from authors on the PGMRA Model

Year: 2019

Type: letter

Abstract: Following publication of our two articles [ 1 , 2 ], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [ 1 , 3 , 4 ] questioned the validity of our results from the perspective of polygenic risk scores (PRS) [ 5 ]. We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approaches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques.

Source: Molecular Psychiatry

DOI: 10.1038/s41380-019-0399-z

Authors: Igor Zwir, Pashupati Mishra, Coral Del-Val, C. Charles Gu, Gabriel A. de Erausquin, Terho Lehtimäki, C. Robert Cloninger

Institutions: Universidad de Granada, Washington University in St. Louis, Tampere University, Fimlab (Finland), University of Tampere, The University of Texas Rio Grande Valley

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,390

OpenAlex ID: W2922022943

Cites: 26

Cited by: 18

Related to: 10