Work

Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 + and TIGIT + CD4 T Cells

Year: 2019

Type: article

Abstract: HIV-1 can establish latent infections that are not cleared by current antiretroviral drugs or the body's immune responses and therefore represent a major barrier to curing HIV-infected individuals. However, the lack of expression of viral antigens on latently infected cells makes them difficult to identify or study. Here, we describe a humanized mouse model that can be used to detect latent but reactivatable HIV-1 in both untreated mice and those on ART and therefore provides a simple system with which to study the latent HIV-1 reservoir and the impact of interventions aimed at reducing it.

Source: Journal of Virology

DOI: 10.1128/jvi.02086-18

Authors: George N. Llewellyn, Eduardo Seclén, Stephen Wietgrefe, Siyu Liu, Morgan Chateau, Hua Pei, Katherine Perkey, Matthew D. Marsden, Sarah J. Hinkley, David E. Paschon, Michael C. Holmes, Jerome A. Zack, Stan G. Louie, Ashley T. Haase, Paula M. Cannon

Institutions: University of Southern California, University of Minnesota, University of California, Los Angeles, Sangamo BioSciences (United States)

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute for Health and Care Research, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases

Awards: G1642211178, HIV-specific nucleases to reservoir cells, Targeted inactivation of HIV in CNS reservoirs, Next Generation HSC Gene Therapy for HIV Control and Eradication, HIV-specific nucleases to reservoir cells, G8789124651

OpenAlex ID: W2922200860

FWCI: 2.623

Cites: 112

Cited by: 29

Related to: 10