Work

Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span

Year: 2019

Type: article

Abstract: associated with periodontitis. Major differences in the top 50 operational taxonomic units (OTUs) were noted in the young and adolescent microbiomes during initiation and progression postligation compared to the adult and aged animals. The proportions of a large number of species in the top 50 OTUs were lower at baseline and in resolved disease microbiomes in the young samples, while profiles in adolescent animals were more consistent with the disease microbiomes. Microbiome profiles for resolution for adults and aged animals appeared more resilient and generally maintained a pattern similar to that of disease. Use of the model can expand our understanding of the crucial interactions of the oral microbiome and host responses in periodontitis.

Source: Infection and Immunity

DOI: 10.1128/iai.00067-19

Authors: Sreenatha Kirakodu, Jin Chen, Janis Gonzalez Martinez, Octavio A. Gonzalez, Jeffrey Ebersole

Institution: University of Kentucky

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Kentucky, National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources