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Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk

Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Individuals with a family history of cancer may be at increased risk of pancreatic cancer. Ashkenazi Jewish (AJ) individuals carry increased risk for pancreatic cancer and other cancer types. METHODS: We examined the association between family history of cancer, AJ heritage, and incident pancreatic cancer in 49 410 male participants of the prospective Health Professionals Follow-up Study. Hazard ratios (HRs) were estimated using multivariable-adjusted Cox proportional hazards models. RESULTS: During 1.1 million person-years (1986-2016), 452 participants developed pancreatic cancer. Increased risk of pancreatic cancer was observed in individuals with a family history of pancreatic (HR, 2.79; 95% confidence interval [CI], 1.28-6.07) or breast cancer (HR, 1.40; 95% CI, 1.01-1.94). There was a trend towards higher risk of pancreatic cancer in relation to a family history of colorectal cancer (HR, 1.21; 95% CI, 0.95-1.55) or AJ heritage (HR, 1.29; 95% CI, 0.94-1.77). The risk was highly elevated among AJ men with a family history of breast or colorectal cancer (HR, 2.61 [95% CI, 1.41-4.82] and 1.92 [95% CI, 1.05-3.49], respectively). CONCLUSION: Family history of pancreatic cancer was associated with increased risk of this malignancy. Family history of breast or colorectal cancer was associated with the increased risk among AJ men.
DOI: 10.1038/s41416-019-0426-5
Authors: Tsuyoshi Hamada, Chen Yuan, Matthew B. Yurgelun, Kimberly Perez, Natalia Khalaf, Vicente Morales-Oyarvide, Ana Babic, Jonathan A. Nowak, Douglas A. Rubinson, Marios Giannakis, Kimmie Ng, Peter Kraft, Meir J. Stampfer, Edward L. Giovannucci, Charles S. Fuchs, Shuji Ogino, Brian M. Wolpin
Institutions: Harvard University, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Broad Institute, Massachusetts Institute of Technology, Yale Cancer Center, Yale University, Smilow Cancer Hospital
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,300
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1160275816, G1416987869, G1652679434, Prospective Cohort Collaborative in Pancreatic Cancer Epidemiology & Pathogenesis, G2652994630, G2789075706, G3101773556, G370776200, G3754462075, G3901341770, G5520316217, G6138329463, G6682102338, Cancer Epidemiology Cohort in Male Health Professionals, G9000000635, G9000043482, G9000050131, G9000122174, G9000131360, G9000207199, G9000240940, Leveraging Novel Randomized Clinical Trials of Vitamin D Supplementation in Patients with Colorectal Cancer: Impact on Survival and Anti-Tumor Immunity, Altered metabolism and machine learning for pancreatic cancer early detection
OpenAlex ID: W2922478895
FWCI: 0.725
Cites: 50
Cited by: 61
Related to: 10