Work

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

Year: 2019

Type: article

Abstract: mutant cancers. In human lung tumor samples, high ZEB1 and low IL17RD expression correlated with low MAPK signaling, presenting potential markers that predict patient response to MEK inhibitors.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aaq1238

Authors: David H. Peng, Samrat T. Kundu, Jared J. Fradette, Lixia Diao, Pan Tong, Lauren A. Byers, Jing Wang, Jaime Rodriguez Canales, Pamela A. Villalobos, Barbara Mino, Yanan Yang, Rosalba Minelli, Michael D. Peoples, Christopher A. Bristow, Timothy P. Heffernan, Alessandro Carugo, Ignacio I. Wistuba, Don L. Gibbons

Institutions: The University of Texas MD Anderson Cancer Center, Mayo Clinic, Mayo Clinic Comprehensive Cancer Center (Minnesota)

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: Targeting Lung Cancer Vulnerabilities, The Role of Epithelial-Mesenchymal Transition in Re-Wiring KRAS Mutant Lung Cancer, Cancer Center Support Grant

OpenAlex ID: W2922513518

FWCI: 2.977

Cites: 61

Cited by: 53

Related to: 10