Visualization of Brain Shift Corrected Preoperative fMRI for Functional Mapping during Awake Brain Surgery
Year: 2018
Type: dissertation
Abstract: Surgical treatment of brain tumors requires careful balance between maximizing tumor excision and preserving eloquent cortex. Often, the patient is kept awake but sedated so that the gold standard technique of direct cortical stimulation (DCS) can be used to map brain function intraoperatively. Preoperatively, functional magnetic resonance imaging (fMRI) facilitates planning by identification of brain areas critical for language and motor function, helping to guide DCS and other aspects of the surgical plan. However, brain deformation during surgery limits the usefulness of preoperative fMRI. To address this, an image registration pipeline has been developed that displays preoperative fMRI data corrected for brain shift overlaid on the exposed cortical surface at the beginning and completion of DCS mapping. This pipeline has been validated on clinical data, providing accuracy comparable to DCS resolution. This multimodality visualization of fMRI and DCS has potential benefits for improving the intraoperative brain mapping process.
Source: TSpace (University of Toronto)
Author: Sanam Ali
Language: English
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2922827158