Chemical Exchange Saturation Transfer MRI for Detection of Cell Death in Breast Cancer Xenografts
Year: 2018
Type: dissertation
Abstract: Detecting cell death after chemotherapy could help optimize treatment regimens and improve outcomes. Breast cancer xenografts (MDA-MB-231) were scanned before and after chemotherapy to investigate parameters of chemical exchange saturation transfer (CEST) MRI that can differentiate regions of cell death from viable tumour. The CEST effect at 0.5 μT saturation amplitude was measured using the magnetization transfer ratio (MTR) at 1.8 and -3.3 ppm frequency offsets. An MTR cutoff of 0.12 at 1.8 ppm was able differentiate between viable tumour and cell death regions (p
Source: TSpace (University of Toronto)
Author: Jonathan Klein
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2923063469