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68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

Year: 2019

Type: article

Abstract: Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68 Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68 Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated ( R 2 = 0.98) with the concentration of lung allysine.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12342

Authors: Jessica Wahsner, Pauline Désogère, Eric Abston, Katherine A. Graham-O’Regan, Junfeng Wang, Nicholas J. Rotile, Markus D. Schirmer, Diêgo Dos Santos Ferreira, Jingyi Sui, Bryan C. Fuchs, Michael Lanuti, Peter Caravan

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, National Heart, Lung, and Blood Institute, NIH Office of the Director

Awards: PET Imaging of Pulmonary Fibrosis, HPLC-ICP-MS System, Electronics Upgrade for 11.7 T, Funktionelle MRT als bildgebendes Verfahren: Design und Synthese von DOTAbasierten Gd Kontrastmitteln für die Nachverfolgung von Neurotransmittern im Gehirn, G7460054480, Biology of the Lung: A Multidisciplinary Program, G996561092

OpenAlex ID: W2923457014

FWCI: 2.309

Cites: 23

Cited by: 38

Related to: 10