Work

Small Molecules As Central Nervous System Therapeutics: Old challenges, New directions, and a Philosophic Divide

Year: 2019

Type: article

Abstract: small molecules have been by far the most successful class of CNS therapeutics.On one hand, common problems, such as when CNS-to-blood transporters prevent their accumulation in the brain, challenge their wider development.On the other hand, new approaches to their use as modulators of BBB transport systems open new possibilities "

Source: Future Medicinal Chemistry

DOI: 10.4155/fmc-2018-0436

Authors: William A Banks, Nigel H Greig

Institutions: University of Washington, VA Puget Sound Health Care System, National Institutes of Health, National Institute on Aging

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2924053103

FWCI: 2.206

Cites: 17

Cited by: 53

Related to: 10