Work

Immune Function of Vitamin D in Type 1 Diabetes Mellitus

Year: 2014

Type: article

Abstract: Vitamin D is a well-known fat-soluble vitamin which is essential in the homeostasis of calcium and phosphorus. Vitamin D deficiency causes skeletal disorders, including rickets, osteomalacia, and osteoporosis. However, recent studies revealing the immunomodulatory effects of vitamin D have opened up a new understanding and possibility in this field. It has been proved that vitamin D is related to a variety of autoimmune diseases. Type 1 diabetes mellitus (T1DM), being generally accepted as autoimmune mediated, is also proposed to be associated with the vitamin D status of the human body. Here, we reviewed briefly the epidemiological correlation between the vitamin D status and prevalence of T1DM, the possible mechanisms underlying this correlation, and clinical trials focusing on the therapeutic prospects of vitamin D in the treatment of T1DM.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Jingbo Li, Bing Xiao, Yufei Xiang

Institutions: Children's Hospital Los Angeles, Central South University, Second Xiangya Hospital of Central South University

Language: English

Topic: Vitamin D Research Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2924154569

FWCI: 0.218

Cites: 47

Cited by: 4

Related to: 10