Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
Year: 2019
Type: article
Abstract: This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a complementary therapy that can be easily incorporated into current workflows. In the future, inhaled hydrogen may diminish the sequelae of ischemia that occurs in congenital heart surgery, cardiac arrest, extracorporeal life-support events, acute myocardial infarction, stroke, and organ transplantation.
Authors: Alexis R. Cole, Dorothy A. Perry, Ali Raza, Arthur P. Nedder, Elizabeth Pollack, William L. Regan, Sarah J. van den Bosch, Brian D. Polizzotti, Edward Yang, Daniel Davila, Onur Afacan, Simon K. Warfield, Yangming Ou, Brenda Sefton, Allen D. Everett, Jeffrey J. Neil, Hart G.W. Lidov, John E. Mayer, John N. Kheir
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,400
OpenAlex ID: W2924267611