Characterization of clinically relevant RNA alterations for personalized cancer medicine
Year: 2019
Type: dissertation
Abstract: The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main issues: the development of computational tools to study RNA profiles from multiple tumors and the identification of RNA-related signatures that may be predictive of prognosis and therapy. The thesis is divided in three chapters: First, the development a new tool for fast quantification of differential splicing: SUPPA2. Second, a new methodology for elucidating the prognostic potential of alternative transcript isoforms across human tumours. And third, a new method for the detection of aberrant tumor splicing junctions and their antigenic evaluation.
Authors: Trincado Alonso, Juan Luís
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2924330899