Work

Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.

Year: 2019

Type: article

Abstract: -deficent MEFs exhibits a high CK2α binding affinity and concomitantly reduces CK2 kinase activity. Permidine treatment activates CK2 by releasing the interaction between lamin A and CK2, promoting DNA damage repair and ameliorating progeroid features. These data reveal a previously unidentified function for nuclear lamin A and highlight an essential role for CK2 in regulating senescence and aging.

Source: Science Advances

DOI: 10.1126/sciadv.aav5078

Authors: Ying Ao, Jie Zhang, Zuojun Liu, Minxian Qian, Yao Li, Zhuping Wu, Pengfei Sun, Jie Wu, Weixin Bei, Junqu Wen, Xuli Wu, Feng Li, Zhongjun Zhou, Wei-Guo Zhu, Baohua Liu, Zimei Wang

Institutions: Wuhan University, Shenzhen University Health Science Center, Shenzhen University, University of Hong Kong

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funder: National Natural Science Foundation of China

Awards: G3189384616, G3716052160, G4301446717, G4331022191, G5870249511

OpenAlex ID: W2924569931

FWCI: 1.557

Cites: 41

Cited by: 34

Related to: 10