Year: 2019
Type: article
Study design: Observational Study
Abstract: The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to the timing of biological and behavioral activities, including when we sleep, eat, and exercise, and later chronotype is associated with longer intrinsic circadian period (cycle length), a fundamental property of the circadian system. Thus, we tested whether this PER2 variant was associated with circadian period and found significant associations with longer intrinsic circadian period as measured under forced desynchrony protocols, the 'gold standard' for intrinsic circadian period assessment. Minor allele (T) carriers exhibited significantly longer circadian periods when determinations were based on either core body temperature or plasma melatonin measurements, as compared to non-carriers (by 12 and 11 min, respectively; accounting for ~7% of inter-individual variance). These findings provide a possible underlying biological mechanism for inter-individual differences in chronotype, and support the central role of PER2 in the human circadian timing system.
Source: Scientific Reports
Authors: Anne-Marie Chang, Jeanne F. Duffy, Orfeu M. Buxton, Jacqueline M. Lane, Daniel Aeschbach, Clare Anderson, Andrew C. Bjonnes, Sean W. Cain, Daniel A. Cohen, Timothy M. Frayling, Joshua J. Gooley, Samuel E. Jones, Elizabeth B. Klerman, Steven W. Lockley, Mirjam Munch, Shantha M. W. Rajaratnam, Melanie Rueger, Martin K. Rutter, Nayantara Santhi, Karine Scheuermaier, Eliza Van Reen, Michael N. Weedon, Charles A. Czeisler, Frank A. J. L. Scheer, Richa Saxena
Institutions: Broad Institute, Brigham and Women's Hospital, Pennsylvania State University, Harvard University, Massachusetts Institute of Technology, Massachusetts General Hospital, Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR), Monash University, University of Exeter, Duke-NUS Medical School, Massey University, Manchester Academic Health Science Centre, University of Manchester, Manchester University NHS Foundation Trust, University of Surrey, University of the Witwatersrand, Brown University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,790
Funders: U.S. Department of Health and Human Services, Brigham and Women's Hospital, Harvard University, Harvard Catalyst, National Space Biomedical Research Institute, National Alliance for Research on Schizophrenia and Depression, Broad Institute, National Institutes of Health, Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, National Center for Complementary and Integrative Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Air Force Office of Scientific Research
Awards: Effect of circadian gene variants on sleep, obesity, and metabolic phenotypes, Leveraging Family Data to Identify Genetic Variants for Sleep Apnea, Disrupted Sleep in the Elderly: Circadian Etiology, G1523888516, Meal Time Effects on Metabolic Health., Effect of Vitamin B12 on the Human Circadian Pacemaker, Sleep Duration Required to Restore Performance during Chronic Sleep Restriction, G2220241606, Multi-scale modeling of sleep behaviors in social networks, Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals, G2275654771, Sensitization of Human Circadian Responses to Light, Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes Risk, Role of age-related alterations of circadian rhythms and sleep in nocturia, G3615943839, Circadian & Genetic Evaluation of Extreme Sleep Timing, Development of countermeasures against adverse metabolic effects of shift work, Mechanisms underlying adverse health consequences of shift work, G4365582495, G4709353266, G4731489385, Sleep, Aging and Circadian Rhythm Disorders, Sleep duration required to restore performance during chronic sleep restriction, Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes, Genetic Analysis of Extreme Circadian/Sleep Phenotypes, Effects of Light and Melatonin on Contractions in Pregnant Women, Neurobiology of Individual Differences in Sleep Duration, G6424384527, Treatment of Circadian Sleep Disorders with Bright Light, G7060033699, G7188459038, Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism, Genetic and molecular basis of circadian rhythm disorders, Efficacy of melatonin treatment in a phase advance model of insomnia, Desensitization of Circadian Responses to Light, G804270614, Harvard Clinical and Translational Science Center, G8340082409, Adaptation of Circadian Responses to Light Treatment, Impact of genetic variants on sleep timing and type 2 diabetes risk, Discovery of genes for sleep traits, Training in Sleep, Circadian, and Respiratory Neurobiology, Genetics of chronotype and impact on metabolic disease
OpenAlex ID: W2924742368