Year: 2017
Type: review
Abstract: The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer.
Authors: Yoku Hayakawa, James G. Fox, Timothy C. Wang
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,430
Funders: Japan Agency for Medical Research and Development, Kobayashi Foundation for Cancer Research, National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: Biomedical Research Training for Veterinary Scientists, The Role of the Microenvironment in Barrett's Esophagus, 印環細胞型胃癌に対する抗炎症剤による腫瘍抑制効果の検討, The Role of Inflammation and Stroma in Digestive Cancer, Function and Regulation of Gastrin, Etiological Studies of Gastric Carcinoma, MIT Center for Environmental Health Sciences, Mouse Models of Gastric Cancer, Stem Cells and Gastric Cancer, G7027797693, The role of stem cells and the microenvironment in gastrointestinal cancers, G967124982
OpenAlex ID: W2589371072